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A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway.

ABSTRACT: Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.

SUBMITTER: Mazein A

PROVIDER: S-EPMC3912678 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway.

Mazein Alexander A Watterson Steven S Hsieh Wei-Yuan WY Griffiths William J WJ Ghazal Peter P

Biochemical pharmacology 20130410 1

Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloc ...[more]

PMID: 23583456

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