Macroglobulin complement-related encodes a protein required for septate junction organization and paracellular barrier function in Drosophila.

ABSTRACT: Polarized epithelia play crucial roles as barriers to the outside environment and enable the formation of specialized compartments for organs to carry out essential functions. Barrier functions are mediated by cellular junctions that line the lateral plasma membrane between cells, principally tight junctions in vertebrates and septate junctions (SJs) in invertebrates. Over the last two decades, more than 20 genes have been identified that function in SJ biogenesis in Drosophila, including those that encode core structural components of the junction such as Neurexin IV, Coracle and several claudins, as well as proteins that facilitate the trafficking of SJ proteins during their assembly. Here we demonstrate that Macroglobulin complement-related (Mcr), a gene previously implicated in innate

SUBMITTER: Hall S 

PROVIDER: S-EPMC3912832 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature