Interaction between stress and the BDNF Val66Met polymorphism in depression: a systematic review and meta-analysis.

ABSTRACT:

Background

Major depression is a disabling psychiatric illness with complex origins. Life stress (childhood adversity and recent stressful events) is a robust risk factor for depression. The relationship between life stress and Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene has received much attention. The aim of the present work was to review and conduct a meta-analysis on the results from published studies examining this interaction.

Methods

A literature search was conducted using PsychINFO and PubMed databases until 22 November 2013. A total of 22 studies with a pooled total of 14,233 participants met the inclusion criteria, the results of which were combined and a meta-analysis performed using the Liptak-Stouffer z-score method.

Results

SUBMITTER: Hosang GM 

PROVIDER: S-EPMC3912923 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature