Decreased expression of key tumour suppressor microRNAs is associated with lymph node metastases in triple negative breast cancer.

ABSTRACT:

Background

Breast cancer is the most common malignancy that develops in women, responsible for the highest cancer-associated death rates. Triple negative breast cancers represent an important subtype that have an aggressive clinical phenotype, are associated with a higher likelihood of metastasis and are not responsive to current targeted therapies. miRNAs have emerged as an attractive candidate for molecular biomarkers and treatment targets in breast cancer, but their role in the progression of triple negative breast cancer remains largely unexplored.

Methods

This study has investigated miRNA expression profiles in 31 primary triple negative breast cancer cases and in 13 matched lymph node metastases compared with 23 matched normal breast tissues to determine miRNAs associa

SUBMITTER: Avery-Kiejda KA 

PROVIDER: S-EPMC3912930 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature