Combination of budesonide/formoterol on demand improves asthma control by reducing exercise-induced bronchoconstriction.

ABSTRACT:

Background

In mild asthma exercise-induced bronchoconstriction (EIB) is usually treated with inhaled short-acting β2 agonists (SABAs) on demand.

Objective

The hypothesis was that a combination of budesonide and formoterol on demand diminishes EIB equally to regular inhalation of budesonide and is more effective than terbutaline inhaled on demand.

Methods

Sixty-six patients with asthma (>12 years of age) with verified EIB were randomised to terbutaline (0.5 mg) on demand, regular budesonide (400 μg) and terbutaline (0.5 mg) on demand, or a combination of budesonide (200 μg)  + formoterol (6 μg) on demand in a 6-week, double-blind, parallel-group study (ClinicalTrials.gov identifier: NCT00989833). The patients were instructed to perform three to four working sessions pe

SUBMITTER: Lazarinis N 

PROVIDER: S-EPMC3913208 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature