Tetramer formation in Arabidopsis MADS domain proteins: analysis of a protein-protein interaction network.

ABSTRACT:

Background

MADS domain proteins are transcription factors that coordinate several important developmental processes in plants. These proteins interact with other MADS domain proteins to form dimers, and it has been proposed that they are able to associate as tetrameric complexes that regulate transcription of target genes. Whether the formation of functional tetramers is a widespread property of plant MADS domain proteins, or it is specific to few of these transcriptional regulators remains unclear.

Results

We analyzed the structure of the network of physical interactions among MADS domain proteins in Arabidopsis thaliana. We determined the abundance of subgraphs that represent the connection pattern expected for a MADS domain protein heterotetramer. These subgraphs were sig

SUBMITTER: Espinosa-Soto C 

PROVIDER: S-EPMC3913338 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature