Familial prostate cancer: the damage done and lessons learnt.

ABSTRACT:

Background

A 51-year-old French Canadian man presented to his family physician owing to an extensive family history of prostate cancer in five brothers, his father and two paternal uncles. His serum PSA level was 4.9 ng/ml and a six-core biopsy revealed the presence of a prostate adenocarcinoma with a Gleason score of 7 (3+4). He was treated with radical prostatectomy. Repeat PSA tests revealed a gradual rise in PSA levels despite androgen deprivation therapy with bicalutamide and goserelin over the course of 3 years. Genetic evaluation was undertaken in view of his personal and family history. The proband died at the age of 58 years of widespread metastasis.

Investigations

PSA testing, six-core biopsy, genetic counselling and mutation analysis for French Canadian founder mu

SUBMITTER: Taherian N 

PROVIDER: S-EPMC3913476 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature