Predicting survival of patients with hypocellular myelodysplastic syndrome: development of a disease-specific prognostic score system.

ABSTRACT:

Background

Although most patients with myelodysplastic syndrome (MDS) exhibit bone marrow hypercellularity, a subset of them present with a hypocellular bone marrow. Specific factors associated with poor prognosis have not been investigated in patients with hypocellular MDS.

Methods

The authors studied a cohort of 253 patients with hypocellular MDS diagnosed at The University of Texas MD Anderson Cancer Center between 1993 and 2007 and a cohort of 1725 patients with hyper-/normocellular MDS diagnosed during the same time period.

Results

Patients with hypocellular MDS presented more frequently with thrombocytopenia (P < .019), neutropenia (P < .001), low serum β-2 microglobulin (P < .001), increased transfusion dependency (P < .001), and intermediate-2/high-risk diseas

SUBMITTER: Tong WG 

PROVIDER: S-EPMC3913560 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature