Serum complement C4b, fibronectin, and prolidase are associated with the pathological changes of pulmonary tuberculosis.

ABSTRACT:

Background

Mycobacterium tuberculosis infection can activate the immune system, leading to characteristic pathological changes such as inflammatory granuloma, caseous necrosis, and cavity formation.

Methods

Clinical data of 187 cases of pulmonary tuberculosis (PTB) were analyzed using statistical methods, while serum levels of complement C4b (C4b), fibronectin (FN), and prolidase (PEPD) were detected using the ELISA method among the control, minimal PTB, moderate PTB, and advanced PTB groups.

Results

We found significantly higher levels of serum C4b and PEPD (P = 0.018, P = 0.003), and significantly lower levels of serum FN (P < 0.001) in PTB patients. Furthermore, the serum levels of 3 proteins were significantly different among 3 PTB groups. FN level was significant

SUBMITTER: Wang C 

PROVIDER: S-EPMC3913605 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature