DNA methylation and regulation of the CD8A after duck hepatitis virus type 1 infection.

ABSTRACT:

Background

Cluster of differentiation 8 (CD8) is expressed in cytotoxic T cells, where it functions as a co-receptor for the T-cell receptor by binding to major histocompatibility complex class I (MHCI) proteins, which present peptides on the cell surface. CD8A is critical for cell-mediated immune defense and T-cell development. CD8A transcription is controlled by several cis-acting elements and trans-acting elements and is also regulated by DNA methylation. However, the epigenetic regulation of CD8A in the duck and its relationship with virus infection are still unclear.

Results

We investigated the epigenetic transcriptional regulatory mechanisms, such as DNA methylation, for the expression of the CD8A and further evaluated the contribution of such epigenetic regulatory mec

SUBMITTER: Xu Q 

PROVIDER: S-EPMC3913717 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature