Dynamics of the two heterochromatin types during imprinted X chromosome inactivation in vole Microtus levis.

ABSTRACT: In rodent female mammals, there are two forms of X-inactivation - imprinted and random which take place in extraembryonic and embryonic tissues, respectively. The inactive X-chromosome during random X-inactivation was shown to contain two types of facultative heterochromatin that alternate and do not overlap. However, chromatin structure of the inactive X-chromosome during imprinted X-inactivation, especially at early stages, is still not well understood. In this work, we studied chromatin modifications associated with the inactive X-chromosome at different stages of imprinted X-inactivation in a rodent, Microtus levis. It has been found that imprinted X-inactivation in vole occurs in a species-specific manner in two steps. The inactive X-chromosome at early stages of imprinted X-inactivat

SUBMITTER: Vaskova EA 

PROVIDER: S-EPMC3913780 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature