Heparan sulfotransferases Hs6st1 and Hs2st keep Erk in check for mouse corpus callosum development.

ABSTRACT: The corpus callosum (CC) connects the left and right cerebral hemispheres in mammals and its development requires intercellular communication at the telencephalic midline mediated by signaling proteins. Heparan sulfate (HS) is a sulfated polysaccharide that decorates cell surface and extracellular matrix proteins and regulates the biological activity of numerous signaling proteins via sugar-protein interactions. HS is subject to regulated enzymatic sulfation and desulfation and an attractive, although not proven, hypothesis is that the biological activity of HS is regulated by a sugar sulfate code. Mutant mouse embryos lacking the heparan sulfotransferases Hs2st or Hs6st1 have severe CC phenotypes and form Probst bundles of noncrossing axons flanking large tangles of midline glial processe

SUBMITTER: Clegg JM 

PROVIDER: S-EPMC3913879 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature