Metabolic consequences of microRNA-122 inhibition in rainbow trout, Oncorhynchus mykiss.

ABSTRACT:

Background

MicroRNAs (miRNAs) are small regulatory molecules which post-transcriptionally regulate mRNA stability and translation. Several microRNAs have received attention due to their role as key metabolic regulators. In spite of the high evolutionary conservation of several miRNAs, the role of miRNAs in lower taxa of vertebrates has not been studied with regard to metabolism. The liver-specific and highly abundant miRNA-122 is one of the most widely studied miRNA in mammals, where it has been implicated in the control of hepatic lipid metabolism. Following our identification of acute postprandial, nutritional and endocrine regulation of hepatic miRNA-122 isomiRNA expression in rainbow trout, we used complementary in silico and in vivo approaches to study the role of miRNA-122 in

SUBMITTER: Mennigen JA 

PROVIDER: S-EPMC3914182 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature