Network analysis of neurodegenerative disease highlights a role of Toll-like receptor signaling.

ABSTRACT: Despite significant advances in the study of the molecular mechanisms altered in the development and progression of neurodegenerative diseases (NDs), the etiology is still enigmatic and the distinctions between diseases are not always entirely clear. We present an efficient computational method based on protein-protein interaction network (PPI) to model the functional network of NDs. The aim of this work is fourfold: (i) reconstruction of a PPI network relating to the NDs, (ii) construction of an association network between diseases based on proximity in the disease PPI network, (iii) quantification of disease associations, and (iv) inference of potential molecular mechanism involved in the diseases. The functional links of diseases not only showed overlap with the traditional classificati

SUBMITTER: Nguyen TP 

PROVIDER: S-EPMC3914352 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature