Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms.

ABSTRACT:

Background

Autophagy is an indispensable lysosomal self-digestion process involved in the degradation of aggregated proteins and damaged organelles. Autophagy is associated with the several pathological processes, including cancer. Cancer stem cells (CSCs) play significant roles in cancer initiation, progression and drug resistance. Recent studies have demonstrated the antitumor activities of plant-derived chemopreventive agent rottlerin (Rott). However, the molecular mechanism by which Rott induces autophagy in breast CSCs has not been investigated.

Results

The objectives of this study were to examine the molecular mechanism by which Rott induces autophagy which leads to apoptosis in breast CSCs. Treatment of breast CSCs with Rott for 24 h resulted in a concentration depend

SUBMITTER: Kumar D 

PROVIDER: S-EPMC3914415 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature