Genome destabilizing mutator alleles drive specific mutational trajectories in Saccharomyces cerevisiae.

ABSTRACT: In addition to environmental factors and intrinsic variations in base substitution rates, specific genome-destabilizing mutations can shape the mutational trajectory of genomes. How specific alleles influence the nature and position of accumulated mutations in a genomic context is largely unknown. Understanding the impact of genome-destabilizing alleles is particularly relevant to cancer genomes where biased mutational signatures are identifiable. We first created a more complete picture of cellular pathways that impact mutation rate using a primary screen to identify essential Saccharomyces cerevisiae gene mutations that cause mutator phenotypes. Drawing primarily on new alleles identified in this resource, we measure the impact of diverse mutator alleles on mutation patterns directly by

SUBMITTER: Stirling PC 

PROVIDER: S-EPMC3914614 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature