Genome-wide association study of extreme longevity in Drosophila melanogaster.

ABSTRACT: Human genome-wide association studies (GWAS) of longevity attempt to identify alleles at different frequencies in the extremely old, relative to a younger control sample. Here, we apply a GWAS approach to "synthetic" populations of Drosophila melanogaster derived from a small number of inbred founders. We used next-generation DNA sequencing to estimate allele and haplotype frequencies in the oldest surviving individuals of an age cohort and compared these frequencies with those of randomly sampled individuals from the same cohort. We used this case-control strategy in four independent cohorts and identified eight significantly differentiated regions of the genome potentially harboring genes with relevance for longevity. By modeling the effects of local haplotypes, we have more power to det

SUBMITTER: Burke MK 

PROVIDER: S-EPMC3914684 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature