Global phylogenomic analysis disentangles the complex evolutionary history of DNA replication in archaea.

ABSTRACT: The archaeal machinery responsible for DNA replication is largely homologous to that of eukaryotes and is clearly distinct from its bacterial counterpart. Moreover, it shows high diversity in the various archaeal lineages, including different sets of components, heterogeneous taxonomic distribution, and a large number of additional copies that are sometimes highly divergent. This has made the evolutionary history of this cellular system particularly challenging to dissect. Here, we have carried out an exhaustive identification of homologs of all major replication components in over 140 complete archaeal genomes. Phylogenomic analysis allowed assigning them to either a conserved and probably essential core of replication components that were mainly vertically inherited, or to a variable and

SUBMITTER: Raymann K 

PROVIDER: S-EPMC3914693 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature