Human cardiosphere-derived cells from advanced heart failure patients exhibit augmented functional potency in myocardial repair.

ABSTRACT:

Objectives

This study sought to compare the regenerative potency of cells derived from healthy and diseased human hearts.

Background

Results from pre-clinical studies and the CADUCEUS (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction) trial support the notion that cardiosphere-derived cells (CDCs) from normal and recently infarcted hearts are capable of regenerating healthy heart tissue after myocardial infarction (MI). It is unknown whether CDCs derived from advanced heart failure (HF) patients retain the same regenerative potency.

Methods

In a mouse model of acute MI, we compared the regenerative potential and functional benefits of CDCs derived from 3 groups: 1) non-failing (NF) donor: healthy donor hearts post-transplantation; 2) MI: p

SUBMITTER: Cheng K 

PROVIDER: S-EPMC3914736 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature