UPEPperoni: an online tool for upstream open reading frame location and analysis of transcript conservation.

ABSTRACT:

Background

Several small open reading frames located within the 5' untranslated regions of mRNAs have recently been shown to be translated. In humans, about 50% of mRNAs contain at least one upstream open reading frame representing a large resource of coding potential. We propose that some upstream open reading frames encode peptides that are functional and contribute to proteome complexity in humans and other organisms. We use the term uPEPs to describe peptides encoded by upstream open reading frames.

Results

We have developed an online tool, termed uPEPperoni, to facilitate the identification of putative bioactive peptides. uPEPperoni detects conserved upstream open reading frames in eukaryotic transcripts by comparing query nucleotide sequences against mRNA sequences wit

SUBMITTER: Skarshewski A 

PROVIDER: S-EPMC3914846 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature