Decreased PGE₂ content reduces MMP-1 activity and consequently increases collagen density in human varicose vein.

ABSTRACT:

Unlabelled

Varicose veins are elongated and dilated saphenous veins. Despite the high prevalence of this disease, its pathogenesis remains unclear.

Aims

In this study, we investigated the control of matrix metalloproteinases (MMPs) expression by prostaglandin (PG)E₂ during the vascular wall remodeling of human varicose veins.

Methods and results

Varicose (small (SDv) and large diameter (LDv)) and healthy saphenous veins (SV) were obtained after surgery. Microsomal and cytosolic PGE-synthases (mPGES and cPGES) protein and mRNA responsible for PGE₂ metabolism were analyzed in all veins. cPGES protein was absent while its mRNA was weakly expressed. mPGES-2 expression was similar in the different saphenous veins. mPGES-1 mRNA and protein were detected in healthy veins and

SUBMITTER: Gomez I 

PROVIDER: S-EPMC3914898 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature