Categorization of upper gastrointestinal symptoms is useful in predicting background factors and studying effects and usages of digestive drugs.

ABSTRACT:

Background

There have been very few reports assessing the relationship between various upper gastrointestinal (GI) symptoms or evaluating each individual upper GI symptom separately.

Methods

Based on the answers to Frequency Scale for the Symptoms of GERD from a large-scale population of healthy adults in Japan, a hierarchical cluster analysis was performed to categorize the typical 12 upper GI symptoms. The associations between the 12 symptoms and 13 background factors were systematically analyzed among the 18,097 digestive drug-free subjects, 364 proton-pump inhibitor (PPI) users, and 528 histamine H₂-receptor antagonist (H₂RA) users.

Results

The derived relationship between the 12 upper GI symptoms suggests the five symptom categories: heartburn (2), dyspepsia (4),

SUBMITTER: Yamamichi N 

PROVIDER: S-EPMC3914954 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature