Mitochondrial dysfunction in autism.

ABSTRACT:

Context

Impaired mitochondrial function may influence processes highly dependent on energy, such as neurodevelopment, and contribute to autism. No studies have evaluated mitochondrial dysfunction and mitochondrial DNA (mtDNA) abnormalities in a well-defined population of children with autism.

Objective

To evaluate mitochondrial defects in children with autism.

Design, setting, and patients

Observational study using data collected from patients aged 2 to 5 years who were a subset of children participating in the Childhood Autism Risk From Genes and Environment study in California, which is a population-based, case-control investigation with confirmed autism cases and age-matched, genetically unrelated, typically developing controls, that was launched in 2003 and is sti

SUBMITTER: Giulivi C 

PROVIDER: S-EPMC3915058 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature