Acute myeloid and chronic lymphoid leukaemias and exposure to low-level benzene among petroleum workers.

ABSTRACT:

Background

High benzene exposure causes acute myeloid leukaemia (AML). Three petroleum case-control studies identified 60 cases (241 matched controls) for AML and 80 cases (345 matched controls) for chronic lymphoid leukaemia (CLL).

Methods

Cases were classified and scored regarding uncertainty by two haematologists using available diagnostic information. Blinded quantitative benzene exposure assessment used work histories and exposure measurements adjusted for era-specific circumstances. Statistical analyses included conditional logistic regression and penalised smoothing splines.

Results

Benzene exposures were much lower than previous studies. Categorical analyses showed increased ORs for AML with several exposure metrics, although patterns were unclear; neither con

SUBMITTER: Rushton L 

PROVIDER: S-EPMC3915135 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature