Protein expression, mRNA expression and gene amplification of DNA methyltransferase 1 in endometrial tumor tissues.

ABSTRACT: Inactivation of tumor suppressor genes by methylation is an important pathway in the multi-step process of carcinogenesis. This aim of this study was to investigate the expression of DNA methyltransferase 1 (DNMT1) which strongly contributes to the methylation process in endometrial normal and tumor tissues. Moreover, a correlation with the expression of hMLH1 and E-cadherin that was inactivated in a number of endometrial cancers was observed. Samples were obtained from 8 cases of normal endometrium, 10 cases of hyperplasia, 11 cases of atypical hyperplasia and 38 cases of carcinoma. DNMT1 expression was correlated with tumor progression (P=0.0023), as well as with the attenuation of hMLH1 and E-cadherin expression (P=0.031 and 0.031, respectively). No attenuation of hMLH1 and E-cadherin e

SUBMITTER: Ikeda S 

PROVIDER: S-EPMC3915343 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature