Hypothesis driven single nucleotide polymorphism search (HyDn-SNP-S).

ABSTRACT: The advent of complete-genome genotyping across phenotype cohorts has provided a rich source of information for bioinformaticians. However the search for SNPs from this data is generally performed on a study-by-study case without any specific hypothesis of the location for SNPs that are predictive for the phenotype. We have designed a method whereby very large SNP lists (several gigabytes in size), combining several genotyping studies at once, can be sorted and traced back to their ultimate consequence in protein structure. Given a working hypothesis, researchers are able to easily search whole genome genotyping data for SNPs that link genetic locations to phenotypes. This allows a targeted search for correlations between phenotypes and potentially relevant systems, rather than utilizing s

SUBMITTER: Swett RJ 

PROVIDER: S-EPMC3916134 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature