Transmission distortion affecting human noncrossover but not crossover recombination: a hidden source of meiotic drive.

ABSTRACT: Meiotic recombination ensures the correct segregation of homologous chromosomes during gamete formation and contributes to DNA diversity through both large-scale reciprocal crossovers and very localised gene conversion events, also known as noncrossovers. Considerable progress has been made in understanding factors such as PRDM9 and SNP variants that influence the initiation of recombination at human hotspots but very little is known about factors acting downstream. To address this, we simultaneously analysed both types of recombinant molecule in sperm DNA at six highly active hotspots, and looked for disparity in the transmission of allelic variants indicative of any cis-acting influences. At two of the hotspots we identified a novel form of biased transmission that was exclusive to the n

SUBMITTER: Odenthal-Hesse L 

PROVIDER: S-EPMC3916235 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature