Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics.

ABSTRACT: Global classification of the human proteins with regards to spatial expression patterns across organs and tissues is important for studies of human biology and disease. Here, we used a quantitative transcriptomics analysis (RNA-Seq) to classify the tissue-specific expression of genes across a representative set of all major human organs and tissues and combined this analysis with antibody-based profiling of the same tissues. To present the data, we launch a new version of the Human Protein Atlas that integrates RNA and protein expression data corresponding to ∼80% of the human protein-coding genes with access to the primary data for both the RNA and the protein analysis on an individual gene level. We present a classification of all human protein-coding genes with regards to tissue-specifi

SUBMITTER: Fagerberg L 

PROVIDER: S-EPMC3916642 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature