PH-Responsive Theranostic Polymer-Caged Nanobins (PCNs): Enhanced Cytotoxicity and T₁ MRI Contrast by Her2-Targeting.

ABSTRACT: A PCN theranostic platform comprises a doxorubicin (DXR)-loaded liposomal core and an acid-sensitive polymer shell that is functionalized with Herceptin and Gd^III-based MRI contrast agents. In vitro testing reveals a 14-fold increase in DXR-based cytotoxicity versus a non-targeted analogue and an 120-fold improvement in cellular Gd^III-uptake in comparison with clinically approved DOTA-Gd^III, leading to significant T₁ MRI contrast enhancement.

SUBMITTER: Hong BJ 

PROVIDER: S-EPMC3916701 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature