An approach to quantifying abnormalities in energy expenditure and lean mass in metabolic disease.

ABSTRACT:

Background/objectives

The objective of this study was to develop approaches to expressing resting energy expenditure (REE) and lean body mass (LM) phenotypes of metabolic disorders in terms of Z-scores relative to their predicted healthy values.

Subjects/methods

Body composition and REE were measured in 135 healthy participants. Prediction equations for LM and REE were obtained from linear regression and the range of normality by the standard deviation of residuals. Application is demonstrated in patients from three metabolic disorder groups (lipodystrophy, n=7; thyrotoxicosis, n=16; and resistance to thyroid hormone (RTH), n=46) in which altered REE and/or LM were characterised by departure from the predicted healthy values, expressed as a Z-score.

Results

REE (kJ/mi

SUBMITTER: Watson LP 

PROVIDER: S-EPMC3916834 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature