Network meta-analysis of margin threshold for women with ductal carcinoma in situ.

ABSTRACT:

Background

Negative margins are associated with reduced risk of ipsilateral breast tumor recurrence (IBTR) for women with ductal carcinoma in situ (DCIS) treated with breast-conserving surgery (BCS). However, there is no consensus about the best minimum margin width.

Methods

We searched the PubMed database for studies of DCIS published in English between January 1970 and July 2010 and examined the relationship between IBTR and margin status after BCS for DCIS. Women with DCIS were stratified into two groups, BCS with or without radiotherapy. We used frequentist and Bayesian approaches to estimate the odds ratios (OR) of IBTR for groups with negative margins and positive margins. We further examined specific margin thresholds using mixed treatment comparisons and meta-regress

SUBMITTER: Wang SY 

PROVIDER: S-EPMC3916966 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature