Association of genetic variants of the α-kinase 1 gene with myocardial infarction in community-dwelling individuals.

ABSTRACT: We previously demonstrated that rs2074380 (G→A, Gly870Ser) and rs2074381 (A→G, Asn916Asp) of the α-kinase 1 gene (ALPK1) were significantly associated with chronic kidney disease (CKD) in individuals with diabetes mellitus. As CKD is a significant risk factor for coronary heart disease, we hypothesized that rs2074380 and rs2074381 of ALPK1 may contribute to the genetic susceptibility to myocardial infarction (MI) through affecting the susceptibility to CKD. The aim of the present study was to investigate a possible association of rs2074380 and rs2074381 with MI in community-dwelling individuals. The study subjects comprised 5,771 community-dwelling individuals (41 subjects with MI and 5,730 controls) who were recruited to a population-based cohort study in Inabe, Japan. The c

SUBMITTER: Fujimaki T 

PROVIDER: S-EPMC3917049 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature