ASA failure: does the combination ASA/clopidogrel confer better long-term vascular protection?

ABSTRACT:

Objective

To assess whether adding clopidogrel to acetylsalicylic acid (ASA) has a long-term protective vascular effect in patients with lacunar stroke while taking ASA.

Methods

Post hoc analysis of 838 patients with ASA failure and recent lacunar stroke from the Secondary Prevention of Small Subcortical Strokes Trial (SPS3) cohort randomly allocated to aspirin (325 mg/day) and clopidogrel (75 mg/day) or placebo. Primary efficacy outcome was stroke recurrence (ischemic and intracranial hemorrhage) and main safety outcome was major extracranial hemorrhage. Patients were followed for a mean period of 3.5 years.

Results

The ASA failure group had a significantly higher risk of vascular events including ischemic stroke when compared with the non-ASA failure group (n = 2,15

SUBMITTER: Cote R 

PROVIDER: S-EPMC3917683 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature