Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease.

ABSTRACT:

Objective

The objective of this study was to determine whether environmental and genetic alterations of neuronal aldehyde dehydrogenase (ALDH) enzymes were associated with increased Parkinson disease (PD) risk in an epidemiologic study.

Methods

A novel ex vivo assay was developed to identify pesticides that can inhibit neuronal ALDH activity. These were investigated for PD associations in a population-based case-control study, the Parkinson's Environment & Genes (PEG) Study. Common variants in the mitochondrial ALDH2 gene were genotyped to assess effect measure modification (statistical interaction) of the pesticide effects by genetic variation.

Results

All of the metal-coordinating dithiocarbamates tested (e.g., maneb, ziram), 2 imidazoles (benomyl, triflumizole), 2

SUBMITTER: Fitzmaurice AG 

PROVIDER: S-EPMC3917685 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature