Progressive myoclonic epilepsies: definitive and still undetermined causes.

ABSTRACT:

Objective

To define the clinical spectrum and etiology of progressive myoclonic epilepsies (PMEs) in Italy using a database developed by the Genetics Commission of the Italian League against Epilepsy.

Methods

We collected clinical and laboratory data from patients referred to 25 Italian epilepsy centers regardless of whether a positive causative factor was identified. PMEs of undetermined origins were grouped using 2-step cluster analysis.

Results

We collected clinical data from 204 patients, including 77 with a diagnosis of Unverricht-Lundborg disease and 37 with a diagnosis of Lafora body disease; 31 patients had PMEs due to rarer genetic causes, mainly neuronal ceroid lipofuscinoses. Two more patients had celiac disease. Despite extensive investigation, we found no

SUBMITTER: Franceschetti S 

PROVIDER: S-EPMC3917687 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature