Lack of association between the PIN1 promoter -667T>C (rs2233679) polymorphism and cancer risk: Evidence from meta-analysis.

ABSTRACT: Peptidyl-prolylcis-trans isomerase NIMA-interacting 1 (PIN1) is a critical catalyst involved in multiple oncogenic signaling pathways. The PIN1 promoter -667T>C (rs2233679) polymorphism plays a role in cancer risk. The association between PIN1 (-667T>C) polymorphism and cancer risk has been previously investigated. However, the available results are inconclusive. To derive a more precise estimation, a meta-analysis of seven published case-control studies including 4,524 cases with different tumor types and 4,561 controls was performed. Published literature from PubMed and EMBASE was retrieved. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the strength of the association. Overall, the results did not suggest any associations bet

SUBMITTER: Tao L 

PROVIDER: S-EPMC3917761 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature