Peripheral interleukin-1ß levels are elevated in chronic tension-type headache patients.

ABSTRACT:

Background

Tension-type headache is the most common form of headache and its chronic form, chronic tension-type headache (CTTH), is one of the most difficult to treat. The etiology of CTTH is not well understood, but is believed to be multifactorial and to vary among individuals. In the present study, the authors sought to identify common mechanisms of CTTH pathology. Empirical studies have implicated various immunomodulatory cytokines as mediators of chronic pain disorders, including CTTH.

Objectives

To determine the role of peripheral cytokines and genetic factors in the development of CTTH.

Methods

A panel of cytokines hypothesized to play a role in the pathogenesis of CTTH was measured using cytometric bead arrays and ELISAs in 56 individuals with CTTH and 42 

SUBMITTER: Della Vedova C 

PROVIDER: S-EPMC3917793 | biostudies-literature | 2013 Nov-Dec

REPOSITORIES: biostudies-literature