Factors affecting glomerular filtration rate, as measured by iohexol disappearance, in men with or at risk for HIV infection.

ABSTRACT:

Objective

Formulae used to estimate glomerular filtration rate (GFR) underestimate higher GFRs and have not been well-studied in HIV-infected (HIV(+)) people; we evaluated the relationships of HIV infection and known or potential risk factors for kidney disease with directly measured GFR and the presence of chronic kidney disease (CKD).

Design

Cross-sectional measurement of iohexol-based GFR (iGFR) in HIV(+) men (n = 455) receiving antiretroviral therapy, and HIV-uninfected (HIV(-)) men (n = 258) in the Multicenter AIDS Cohort Study.

Methods

iGFR was calculated from disappearance of infused iohexol from plasma. Determinants of GFR and the presence of CKD were compared using iGFR and GFR estimated by the CKD-Epi equation (eGFR).

Results

Median iGFR was higher am

SUBMITTER: Margolick JB 

PROVIDER: S-EPMC3917840 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature