Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent.

ABSTRACT: Signals from the tumor microenvironment trigger cancer cells to adopt an invasive phenotype through epithelial-mesenchymal transition (EMT). Relatively little is known regarding key signal transduction pathways that serve as cytosolic bridges between cell surface receptors and nuclear transcription factors to induce EMT. A better understanding of these early EMT events may identify potential targets for the control of metastasis. One rapid intracellular signaling pathway that has not yet been explored during EMT induction is calcium. Here we show that stimuli used to induce EMT produce a transient increase in cytosolic calcium levels in human breast cancer cells. Attenuation of the calcium signal by intracellular calcium chelation significantly reduced epidermal growth factor (EGF)- and hy

SUBMITTER: Davis FM 

PROVIDER: S-EPMC3917976 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature