Net reclassification indices for evaluating risk prediction instruments: a critical review.

ABSTRACT: Net reclassification indices have recently become popular statistics for measuring the prediction increment of new biomarkers. We review the various types of net reclassification indices and their correct interpretations. We evaluate the advantages and disadvantages of quantifying the prediction increment with these indices. For predefined risk categories, we relate net reclassification indices to existing measures of the prediction increment. We also consider statistical methodology for constructing confidence intervals for net reclassification indices and evaluate the merits of hypothesis testing based on such indices. We recommend that investigators using net reclassification indices should report them separately for events (cases) and nonevents (controls). When there are two risk categ

SUBMITTER: Kerr KF 

PROVIDER: S-EPMC3918180 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature