Self-reported sleep and β-amyloid deposition in community-dwelling older adults.

ABSTRACT:

Importance

Older adults commonly report disturbed sleep, and recent studies in humans and animals suggest links between sleep and Alzheimer disease biomarkers. Studies are needed that evaluate whether sleep variables are associated with neuroimaging evidence of β-amyloid (Aβ) deposition. OBJECTIVE To determine the association between self-reported sleep variables and Aβ deposition in community-dwelling older adults.

Design, setting, and participants

Cross-sectional study of 70 adults (mean age, 76 [range, 53-91] years) from the neuroimaging substudy of the Baltimore Longitudinal Study of Aging, a normative aging study. EXPOSURE Self-reported sleep variables. MAIN OUTCOMES AND MEASURES β-Amyloid burden, measured by carbon 11-labeled Pittsburgh compound B positron emission tom

SUBMITTER: Spira AP 

PROVIDER: S-EPMC3918480 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature