Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1.

ABSTRACT: In response to viral infection, the host induces over 300 IFN-stimulated genes (ISGs), which are the central component of intracellular antiviral innate immunity. Inefficient induction of ISGs contributes to poor control and persistence of hepatitis C virus infection. Therefore, further understanding of the hepatocytic ISG regulation machinery will guide us to an improved management strategy against hepatitis C virus infection. In this study, comprehensive genome-wide, high-throughput cDNA screening for genes regulating ISG expression identified a tyrosine kinase nonreceptor 1 (TNK1) as a unique player in the ISG induction pathway. The immune-modulatory function of TNK1 has never been studied, and this study characterizes its significance in antiviral innate immunity. TNK1 is abundantly ex

SUBMITTER: Ooi EL 

PROVIDER: S-EPMC3918791 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature