Additive influence of genetic predisposition and conventional risk factors in the incidence of coronary heart disease: a population-based study in Greece.

ABSTRACT:

Objectives

An additive genetic risk score (GRS) for coronary heart disease (CHD) has previously been associated with incident CHD in the population-based Greek European Prospective Investigation into Cancer and nutrition (EPIC) cohort. In this study, we explore GRS-'environment' joint actions on CHD for several conventional cardiovascular risk factors (ConvRFs), including smoking, hypertension, type-2 diabetes mellitus (T2DM), body mass index (BMI), physical activity and adherence to the Mediterranean diet.

Design

A case-control study.

Setting

The general Greek population of the EPIC study.

Participants and outcome measures

477 patients with medically confirmed incident CHD and 1271 controls participated in this study. We estimated the ORs for CHD by dividing p

SUBMITTER: Yiannakouris N 

PROVIDER: S-EPMC3918976 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature