REEP1 and REEP2 proteins are preferentially expressed in neuronal and neuronal-like exocytotic tissues.

ABSTRACT: The six members of the Receptor Expression Enhancing Protein (REEP) family were originally identified based on their ability to enhance heterologous expression of olfactory receptors and other difficult to express G protein-coupled receptors. Interestingly, REEP1 mutations have been linked to neurodegenerative disorders of upper and lower motor neurons, hereditary spastic paraplegia (HSP) and distal hereditary motor neuropathy type V (dHMN-V). The closely related REEP2 isoform has not demonstrated any such disease linkage. Previous research has suggested that REEP1 mRNA is ubiquitously expressed in brain, muscle, endocrine, and multiple other organs, inconsistent with the neurodegenerative phenotype observed in HSP and dHMN-V. To more fully examine REEP1 expression, we developed and charac

SUBMITTER: Hurt CM 

PROVIDER: S-EPMC3919455 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature