Facilitation of memory encoding in primate hippocampus by a neuroprosthesis that promotes task-specific neural firing.

ABSTRACT:

Objective

Memory accuracy is a major problem in human disease and is the primary factor that defines Alzheimer's, ageing and dementia resulting from impaired hippocampal function in the medial temporal lobe. Development of a hippocampal memory neuroprosthesis that facilitates normal memory encoding in nonhuman primates (NHPs) could provide the basis for improving memory in human disease states.

Approach

NHPs trained to perform a short-term delayed match-to-sample (DMS) memory task were examined with multi-neuron recordings from synaptically connected hippocampal cell fields, CA1 and CA3. Recordings were analyzed utilizing a previously developed nonlinear multi-input multi-output (MIMO) neuroprosthetic model, capable of extracting CA3-to-CA1 spatiotemporal firing patterns dur

SUBMITTER: Hampson RE 

PROVIDER: S-EPMC3919468 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature