Stress-induced changes in gene interactions in human cells.

ABSTRACT: Cells respond to variable environments by changing gene expression and gene interactions. To study how human cells response to stress, we analyzed the expression of >5000 genes in cultured B cells from nearly 100 normal individuals following endoplasmic reticulum stress and exposure to ionizing radiation. We identified thousands of genes that are induced or repressed. Then, we constructed coexpression networks and inferred interactions among genes. We used coexpression and machine learning analyses to study how genes interact with each other in response to stress. The results showed that for most genes, their interactions with each other are the same at baseline and in response to different stresses; however, a small set of genes acquired new interacting partners to engage in stress-specif

SUBMITTER: Nayak RR 

PROVIDER: S-EPMC3919594 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature