Interleukin-10 regulates hepcidin in Plasmodium falciparum malaria.

ABSTRACT:

Background

Acute malarial anemia remains a major public health problem. Hepcidin, the major hormone controlling the availability of iron, is raised during acute and asymptomatic parasitemia. Understanding the role and mechanism of raised hepcidin and so reduced iron availability during infection is critical to establish evidence-based guidelines for management of malaria anemia. Our recent clinical evidence suggests a potential role of IL-10 in the regulation of hepcidin in patients with acute P. falciparum malaria.

Methods

We have measured secretion of hepcidin by primary macrophages and the hepatoma cell line HepG2 stimulated with IL-10, IL-6 and Plasmodium falciparum-infected erythrocytes.

Findings

We have observed that IL-10 and IL-6 production increased in primar

SUBMITTER: Huang H 

PROVIDER: S-EPMC3919761 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature