A distinct fatty acid profile underlies the reduced inflammatory state of metabolically healthy obese individuals.

ABSTRACT:

Background

Obesity is associated with numerous health complications; however, a subgroup of obese individuals (termed the metabolically healthy obese or MHO) appear to have lower risk for complications such as type 2 diabetes and cardiovascular disease. Emerging evidence suggests that MHO individuals have reduced inflammation compared to their metabolically unhealthy obese (MUO) counterparts. As it is recognized that fatty acids (FAs) have a strong relationship with inflammation, the current study aimed to uncover if the reduced inflammation observed in MHO individuals is mirrored by a more favourable FA profile.

Methods

Fasted serum samples were collected from lean healthy (LH), MHO, and MUO participants (n = 10/group) recruited from the Diabetes Risk Assessment study. A pa

SUBMITTER: Perreault M 

PROVIDER: S-EPMC3919777 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature