Zebrafish nephrogenesis is regulated by interactions between retinoic acid, mecom, and Notch signaling.

ABSTRACT: The zebrafish pronephros provides a conserved model to study kidney development, in particular to delineate the poorly understood processes of how nephron segment pattern and cell type choice are established. Zebrafish nephrons are divided into distinct epithelial regions that include a series of proximal and distal tubule segments, which are comprised of intercalated transporting epithelial cells and multiciliated cells (MCC). Previous studies have shown that retinoic acid (RA) regionalizes the renal progenitor field into proximal and distal domains and that Notch signaling later represses MCC differentiation, but further understanding of these pathways has remained unknown. The transcription factor mecom (mds1/evi1 complex) is broadly expressed in renal progenitors, and then subsequently

SUBMITTER: Li Y 

PROVIDER: S-EPMC3920184 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature