Computational large-scale mapping of protein-protein interactions using structural complexes.

ABSTRACT: Although the identification of protein interactions by high-throughput methods progresses at a fast pace, "interactome" datasets still suffer from high rates of false positives and low coverage. To map the interactome of any organism, this unit presents a computational framework to predict protein-protein or gene-gene interactions utilizing experimentally determined evidence of structural complexes, atomic details of binding interfaces and evolutionary conservation.

SUBMITTER: Shoemaker B 

PROVIDER: S-EPMC3920302 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature